An introduction to nutribiosis
These three functional areas of animal health – nutrition, microbiome and gut and immune function – are not new to animal producers. However, the industry has traditionally been looking at them in a siloed way. At DuPont Animal Nutrition we believe in a more holistic approach. The understanding of how they interact and impact each other is crucial, and is what makes Nutribiosis unique compared with other gut health concepts in the market.
The Three Components of Nutribiosis
Ensuring that the animal has all the nutrients needed to reach its full potential. It is also important to either limit the amount of undigested nutrients or control the types of undigested nutrients that reach the terminal ileum, so that we don’t provide substrates on which the non-beneficial bacterial populations can feed and thrive.
The diversity of microorganism is key: where beneficial bacteria outnumber non-beneficial bacteria, keeping possible opportunistic pathogens under control. This avoids the occurrence of sub-clinical and clinical disease challenges that would otherwise reduce overall performance and profitability.
Gut & Immune Function
They are vital to allow animals to maximize nutrient absorption and deal with challenges when they occur - whether they are bacterial, viral or environmental. Any immune response mounted by the animal uses energy and can negatively impact growth if the immune response is sustained or uncontrolled.
A holistic view
We believe that taking a holistic view, which considers how everything that is fed to an animal combines and interacts in the GIT, is the way forward. It’s the driving force behind nutribiosis – an approach developed to provide new insights and help animal producers to:
- Make more profitable decisions
- Improve animal performance
- Improve animal welfare
- Improve gut health
‘Nutribiosis has become an integrated part of the innovation work we are doing’
The state of Nutribiosis
Nutribiosis is a state - and as such, it can be favourable or unfavourable. Achieving and maintaining the optimum balance between these three components - known as a “favourable nutribiotic state” - is crucial for good GIT health in an animal, which in turn helps to maximise performance. However, the fragile environment of the GIT means that it is susceptible to a range of external factors, such as climate, environment or disease, which can throw this trinity off-balance.
To explain the value of Nutribiosis it is helpful to look at it in the context of a number of examples: where different interactions between its three pillars lead to a “favourable” or “unfavourable” nutribiotic state, and a corresponding positive or negative outcome in the animal.
Favourable Nutribiotic State:
Poultry: The use of Syncra® AVI, our unique enzyme and multi-strain probiotic solution, in feed formulation positively influences the nutribiotic state - even for low challenge birds. This includes improving intestinal integrity and gut health, enhancing digestibility of starch, fat and protein as well as increasing beneficial bacteria populations versus non-beneficial equivalents
Swine: Our adaptive protease and probiotic solution, Syncra® SWI, has been shown to improve key interactions within the GIT in grower and finisher pigs. It works to improve gut barrier strength through tighter junctions, enhances protein digestibility, amino acid utilisation and fibre bound nutrient release, as well as positively impacting the microbiome function in a number of important ways
Phytase: Axtra® PHY, the fastest-acting phytase, breaks down phytate quickly before it binds the protein, avoiding the anti-nutritive effect and improving nutrient uptake for a healthier, better functioning gut. Ultimately, this results in less undigested protein reaching the caeca or hind gut, reducing protein fermentation and potentially reducing ammonia production, contributing to a favourable nutribiotic state
Unfavourable Nutribiotic State:
Poultry: Necrotic enteritis is a condition which arises from a combination of an intestinal challenge - such as coccidiosis - and an overload of nutrients in the latter part of the intestinal tract. The opportunistic pathogen, C. perfringens, thrives on the high levels of undigested protein that are present; causing intestinal damage and negatively impacting gut function
Swine: High protein diets are associated with swine dysentery. This is due to its low nutrient digestibility which, when combined with poor management practices, can cause increased prevalence of Brachyspira hyodysentariae. This spirochaetal bacterium induces excessive inflammation and necrosis of the epithelial surface of the caecum and colon (large intestine) and diarrhoea
Phytate: phytate binds protein in the upper GIT, making it unavailable to the animal, resulting in increased acid and pepsin production in the stomach. This increases acidity so as the stomach empties it can damage the gut absorptive surface and requires more buffering through release of sodium bicarbonate. The increased demand for sodium negatively effects gut function by depleting sodium levels in cells, reducing the functionality of the sodium pumps required for key nutrient such as glucose and amino acids absorption
As leaders in both enzyme and gut health technologies, we aim to realise the full potential of Nutribiosis by leveraging our extensive expertise encompassing: