“The backbone proteins we engineer come from nature – say from soil where the temperature is moderate and the pH neutral. We might want to ask that enzyme to perform at 30°- 60°C in a high-alkaline environment.
Structural Biology enables us to look at the 3-D structure of the enzyme. That helps us identify which sites or regions to manipulate to achieve the desired performance in the final product.
That is crucial, because the number of possible variants is effectively infinite. So visualizing the structure in 3-D eliminates an immense number of potential experiments, allowing faster selection of the enzymes to go forward into high-throughput screening.
Or to put it another way, the technology increases our success rate. And that enables much faster optimization, helping to accelerate the development of innovative bio-solutions.”